A soundtrack for the 2000 film Me, Myself & Irene was released on CD around the world and contained fifteen songs. This two-disc special edition contains and additional twenty-three songs as heard in the film.
 
Disc One
01. Foo Fighters – Breakout
02. Smash Mouth – Do it Again
03. Third Eye Blind – Deep Inside of You
04. The Offspring – Totalimmortal
05. Ellis Paul – The World Ain’t Slowin’ Down
06. Wilco – Any Major Dude Will Tell You
07. Ivy – Only a Fool Would Say That
08. Hootie & The Blowfish – Can’t Find the Time to Tell You
09. Brian Setzer Orchestra – Bodhisattva
10. The Push Stars – Bad Sneakers
11. Marvelous 3 – Reelin’ in the Years
12. Pete Yorn – Strange Condition
13. Ben Folds Five – Barrytown
14. Billy Goldrum – Razor Boy
15. Tom Wolfe – Where He Can Hide
 
Disc Two
01. Junior Brown – Highway Patrol
02. Bret Reilly – It’s Alright
03. Wagner-Lohengrin – Wedding March
04. Tom Wolfe  – Where He Can Hide
05. Bob Dylan – Blowin’ In The Wind
06. XTC – I‘d Like That
07. Sydney Dale – Making The Changes
08. Hardknox – Fire Like This
09. Cake – Hem Of Your Garment
10. Gerardo Matos Rodriguez – La Cumparcita
11. Pete Yorn – Just Another
12. The Dwarves – Motherfucker
13. Freedy Johnston – Monkey In Your Soul
14. Paddy Kingsland – Fun At The Fair
15. Hipster Daddy-O & The Handgrenades – Perpetrator
16. Sally Taylor & Chris Soucy – Don’t Say You Remember
17. Jimmy Luxury & Tommy Rome Orch. – Sentimental Guy
18. Jimmy Luxury & Tommy Rome Orch.  – I Love Life
19. Jimmy Luxury & Tommy Rome Orch.  – Love Me Cha Cha
20. Kool & The Gang – Celebration
21. Lerner & Loewe – Thank Heaven For Little Girls
22. JP Sousa – El Capitan
23. Steely Dan – Do It Again